what is phenylketonurics in drinkswhat is phenylketonurics in drinks

But it is usually included on labels to warn phenylketonurics a group of people. Studies suggest that there's a higher risk among people of Native American or European descent. Phenylketonurics, referring to people with Phenylketonuria (PKU) which is a genetic disease that affects the metabolism of the amino acid, phenylalanine. Aspartame is an artificial sweetener made with phenylalanine. Phenylketonuria (PKU) is a genetic condition that causes elevated levels of a substance called phenylalanine to build up in your body. Clinical Nutrition. See the next article in the aspartame series:Exaggerated Claims About the Harmful Effects of Aspartame. They have a 25% chance of having an affected child with two changed genes (right). Most often, PKU is passed to children by two parents who are both carriers of the changed gene, but don't know it. Most people can turn Phenylalanine into Tyrosine in their cells and then use the Tyrosine. Even if you dont have PKU, you should still go for genetic counseling if any of your close relatives have PKU. These days, most doctors that provide care for PKU patients preach that the low protein PKU diet should be a way of life and, if we value our health and well-being, those of us with the disorder should never stray from it. Any amino acids that are not needed are broken down further and . A single copy of these materials may be reprinted for noncommercial personal use only. Classic phenylketonuria. A single copy of these materials may be reprinted for noncommercial personal use only. Since PKU is a genetic condition, a genetic test can pinpoint the mutation responsible for symptoms. Amino acids are the building blocks of. It is not recommended that PKU heterozygotes consume a special diet. There is a particular concern among parents about the supposed harm of phenylalanine from aspartame in their childrens diet. health information, we will treat all of that information as protected health It informs people with PKU that there is phenylalanine in the product. Whether they are babies, children, or adults, phenylketonurics must limit Phe in their diet. About & Disclaimer | Terms | Privacy | Contact, Amino Acids and their Structure and Function, How Proteins are Broken down into Amino Acids, What Does a Positive TB Test Look Like? Phenylalanine is found in a large number of foods, including chicken, eggs, milk, beef, soybeans, and pork. High levels of phenylpyruvic acid damage the brain and can cause an array of side effects - mental retardation, the loss of pigmentation in the skin/hair/eyes (people with untreated PKU often have light skin, blond hair and blue eyes), a "mousy" or musty odor, muscle aches and pains and in extreme cases, even seizures. Bodamer OA. 2021; doi:10.1038/s41572-021-00267-0. In most cases, PKU is caused by changes (pathogenic variants, also called genetic changes ) in the PAH gene. Zeratsky KA (expert opinion). In the past, children were taken off the low protein PKU diet at age 5 or 6 because it was believed that at this age the brain had developed to the point where elevated levels of phenylpyruvic acid in the blood would not cause severe health problems. Many of the foods you eat that contain protein and the artificial sweetener aspartame have phenylalanine. One question that I often get asked by people who read this webpage - "Is phenylalanine harmful to people that don't have PKU?". Aspartame is the artificial sweetener in some sodas that make them unsuitable for people with PKU. Last reviewed by a Cleveland Clinic medical professional on 08/15/2022. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Phenylalanine is an amino acid contained in proteins such as meats, milk, cheese as well as in nuts. Phenylalanine isn't a health concern for most people. Phe is one of many amino acids. "Phenylketonurics" is the term used to refer to people that have the metabolic disorder Phenylketonuria, or PKU for short. This means that babies receive one copy of the mutated gene that causes PKU from each parent during conception. information highlighted below and resubmit the form. But if your child will have PKU due to inheritance, both you and your partner would have to pass on defective genes to the child. You may opt-out of email communications at any time by clicking on I want to note that I am NOT a medical professional (my Ph.D. is in Astronomy, not medicine), and you should never make important decisions about your health without the guidance of a medical specialist. Advertising on our site helps support our mission. So it builds up to toxic levels. Body Fat Percentage Calculator (for Women and Men), Optislim! Without this enzyme, the body cant process this amino. Remember that if you have this condition, you would have to abstain from protein. Phenylalanine is an amino acid. The condition inherits as an autosomal recessive condition or a condition which manifests only when both parents are carriers of the defective gene. Accessed Jan. 28, 2022. Excessive phenylalanine can be metabolized into phenylketones through the minor route, a transaminase pathway with glutamate.Metabolites include phenylacetate, phenylpyruvate and phenethylamine. Protein-rich foods usually contain lots of Phe. https://www.genome.gov/25020037/learning-about-phenylketonuria/. Phenylketonuria (fen-ul-key-toe-NU-ree-uh), also called PKU, is a rare inherited disorder that causes an amino acid called phenylalanine to build up in the body. Phenylalanine occurs naturally in many protein-rich foods, such as milk, eggs and meat. Meanwhile, people with PKU usually have a challenge with protein foods generally. This content does not have an English version. High levels of phenylpyruvic acid damage the brain and can cause an array of side effects - mental retardation, the loss of pigmentation in the skin/hair/eyes (people with untreated PKU often have light skin, blond hair and blue eyes), a "mousy" or musty odor, muscle aches and pains and in extreme cases, even seizures. This is achieved through diet formulations, protein supplements, and enzyme substitutions. These symptoms may be different from person to person. privacy practices. information is beneficial, we may combine your email and website usage information with Accessed Jan. 28, 2022. However, for people who have the genetic disorder phenylketonuria (PKU) or certain other health conditions phenylalanine can be a serious health concern. I have seen the effects of aspartame toxicity and have discussed symptoms of aspartame poisoning with literally hundreds of people who have found this website. However, for foods which are artificially formulated with phenylalanine-containing ingredients, it becomes necessary to give Phenylketonurics the heads-up. Phenylketonuria (fen-ul-keetone-YU-ree-ah, or PKU) is an inherited metabolic disorder in which the body cannot completely break down the protein (amino acid) phenylalanine. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Light skin and hair, seizures, developmental delays, behavioral problems, and psychiatric disorders are also common. In children with phenylketonuria, the gaining of height would be noticeably reduced and the brain growth would also be less as depicted by small head circumference. It is also a component of some medications. information highlighted below and resubmit the form. Eunice Kennedy Shriver National Institute of Child Health and Human Development. } Because of this, use products with aspartame cautiously if you: If you aren't sure if phenylalanine or aspartame is a concern for you, talk to your doctor. Humans cannot make phenyalanine, but it is a natural part of the foods we eat. You might have PKU because you were born with a defective gene. This means phenylalanine builds up in the person's blood, urine, and body. Age of onset can vary for different diseases and may be used by a doctor to determine the diagnosis. Sodium to Salt Calculator (Salt to Sodium Conversion), My Muscle Chef Review (we eat the curry! It's possible for a parent to be a carrier to have the changed gene that causes PKU, but not have the disease. For some diseases, symptoms may begin in a single age range or several age ranges. Phenylketonuria. Last updated on Dec 13, 2022. If left untreated, phenylketonuria can affect a persons cognitive development. https://newbornscreening.hrsa.gov/conditions/classic-phenylketonuria. Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. For people without PKU or other metabolic disorders, it is very important to eat a balanced diet, and this certainly includes high protein (high phenylalanine) foods. Take certain medications, such as monoamine oxidase inhibitors, neuroleptics or medications that contain levodopa (Sinemet, Rytary, others), Have the muscle movement disorder tardive dyskinesia, Have a sleep disorder, anxiety disorder or other mental health condition; phenylalanine may worsen feelings of anxiety and jitteriness. In the same vein, phenylketonurics are those people who have phenylketonuria. However, the amount of phenylalanine provided by aspartame is unidentifiable from food and drinks labels. People with phenylketonuria can't metabolize phenylalanine. Healthcare providers confirm a diagnosis of phenylketonuria (PKU) shortly after birth as part of routine newborn screening via a blood test. the unsubscribe link in the e-mail. Phenylketonurics is a term that describes those who have PKU. information submitted for this request. When aspartame metabolises (as your body digests it), it forms phenylalanine. Is it something you can catch from diet soda? Lunch: low protein Mac & Cheese, applesauce, veggie crackers, fruit chewies This diet has been specifically designed for children diagnosed with PKU and should not be used for a child without PKU. If you buy frozen vegetables, make sure there's no cream or cheese sauce, which will add additional protein and phenylalanine. Weird, huh? New York: Marshall Cavendish, 1998.2. People with the condition lack the enzyme phenylalanine hydroxylase, necessary to deal with the amino acid phenylalanine. This includes drinks like black coffee. digestive health, plus the latest on health innovations and news. Research increases what we know about rare diseases so that people can get a diagnosis more quickly and can know what to expect. I personally know of several people who refuse to drink diet soda because the word "phenylketonurics" sounds too scary! High-intensity sweeteners. What is Phenylketonuria (PKU)? Tim Tam Calories, Ingredients, and the infamous TimTamSlam, Kilojoules to Calories (kJ to Cal) Converter, Calorie Deficit Calculator (To Lose Weight). Keep in mind that since children are rapidly growing, they already take in a much higher proportion of phenylalanine than adults do. This content does not have an Arabic version. However, if you think you may be experiencing effects of aspartame poisoning, I recommend an easy test - avoid all aspartame containing products for 1 month. Phenylketonuria. Phenylketonurics is a term that describes those who have PKU. If you have seen a nutrition label with these scary words and wondered what they mean exactly, this quick post is for you! Teach your child to also avoid foods and medicine containing aspartame. I hope this webpage has answered some of the questions you originally went searching for regarding the scary-sounding warning: Phenylketonurics - Contains Phenylalanine! Eunice Kennedy Shriver National Institute of Child Health and Human Development. Depending on the severity of the PKU, babies who were not treated for the disorder and put on the special diet at birth run the risk of suffering irreversible mental retardation within the first year of life. Mothers who have PKU and no longer follow a phenylalanine-restricted diet have an increased risk of having children with an intellectual disability, because their children may be exposed to very high levels of phenylalanine before birth. This warning helps people with PKU avoid products that are a source of phenylalanine. Rare disease umbrella organizations focus on improving the lives of all those impacted by rare diseases through education and advocacy efforts. Firman S, et al. Apart form this, it is possible for the child to develop fits or else abnormal movements of the limbs as in epilepsy type of seizures. Its the version of milk. But some people can not. If babies are put on the low protein diet at a young age, and they follow the diet throughout life, there is no evidence that their PKU will be a major hindrance in their accomplishments. Current clinical studies can be found by using ClinicalTrials.gov(see below). We do not endorse non-Cleveland Clinic products or services. . https://naturalmedicines.therapeuticresearch.com. Phenylalanine can cause intellectual disabilities, brain damage, seizures and other problems in people with PKU. Often you'll find that information on a label like you do on the soda cans. It is believed that aspartame can cause a wide range of side effects - from stomach problems, to headaches, nausea and skin rashes. Sometimes, a child might inherit defective genes from parents. Mayo Clinic. Out of 500 babies which do test positive for PKU on the first test, on average only one will actually have the disorder. Well, this warning exists because phenylalanine is dangerous to some people who have a very rare disease known as phenylketonuria. PKU formulas are special nutritional supplements that phenylketonurics might have to take for life. Thus, the accumulated phenylalanine levels will give rise to following symptoms. You should avoid foods that are high in protein, such as meat, eggs and dairy products. Phenylketonuria is a genetic metabolic disorder that results when the PKU gene is inherited from both parents. What is the Difference Between Convection and Induction Cooking? If your symptoms are caused by aspartame poisoning then you should feel better within this month. Autosomal means the gene is located on any chromosome except the X or Y chromosomes (sex chromosomes). Some researchers claim that the amino acid phenylalanine is a natural muscle relaxer and sleep aid. Although there is no cure for PKU, recognizing PKU and starting treatment right away can help prevent limitations in areas of thinking, understanding and communicating (intellectual disability) and major health problems. However, children with mild PKU still have to watch their diet because they are still in their formative years. One question that I often get asked by people who read this webpage - "Is phenylalanine harmful to people that don't have PKU?". Answer (1 of 3): It's best to just read Phenylketonuria - Wikipedia on this one. It may even help improve diagnosis and treatment of more common diseases. Please feel free to send me an email: kineala@mac.com with comments/suggestions on your case or on improving this website. Babies in the United States and many other countries are screened for PKU soon after birth. Women who have PKU and become pregnant are at risk of another form of the condition called maternal PKU. When babies are born in the United States, a heel stick blood test is done to test for various disorders - PKU is one of the disorders that is tested for. They also have to track what she/he eats and how much she/he eats each day. Some food products include the warning: Phenylketonurics: Contains Phenylalanine. .st2 { One cup (240 ml) of black coffee contains about 3 calories and very small amounts of protein, fat, and trace . Phenylketonurics does not refer to any condition you can get because you drank a can of soda. Phenylalanine is also sold as a dietary supplement. Hayes, A. W. Artificial Sweeteners: A Special Issue of the Journal Comments on Toxicology.Comments on Toxicology III (1989)3. 2019; doi:10.1007/s40265-019-01079-z. In the United States, phenylketonuria (PKU) affects an estimated 1 in every 10,000 to 15,000 newborns each year. Electronic Code of Federal Regulations. When women with PKU have high blood phenylalanine levels during pregnancy, it can harm their unborn baby. Many rare diseases have limited information. Thats why it might be important to go for genetic counseling with your partner if you are phenylketonuric. .st0 { Available for Android and iOS devices. Accessed July 3, 2018. If you have PKU and you eat any protein food or a product with aspartame, it would cause serious health issues. In most cases, parents are carriers of the gene but dont have symptoms of the condition. Accessed July 3, 2018. PKU is a lifelong condition, and staying regular with your diet and appointments to check the phenylalanine levels in your blood makes positive, lifelong habits that lead to good health. Phenylketonuria (PKU) is a genetic metabolic disorder that increases the body's levels of phenylalanine. A blood test to determine if you have PKU is available and is now routinely done as part of newborn screening. Mutation is an older term that is still sometimes used to mean pathogenic variant. Aspartame in large doses can cause a rapid increase in brain levels of phenylalanine. Newborns receive this test between 24 to 72 hours after birth as part of the newborn screen. The New Public Health. Please contact for permissions. Phenylalanine is found in many foods, such as meat, poultry, fish, eggs, milk, cheese, beans, nuts, and seeds. Palynziq (prescribing information). Overview of phenylketonuria. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Phenylketonuria is a genetic metabolic disorder that results when the PKU gene is inherited from both parents. I myself, am one of these phenylketonurics and the warning on diet soda cans is included merely to inform people like me that the product contains the synthetic chemical ASPARTAME . Phenylalanine - Aspartame. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Babies born to women with high phenylalanine levels don't often inherit PKU. If a baby is tested positive for PKU at birth, a follow up test is done a few days later. People that have the disorder PKU cannot consume any product that contains aspartame, for reasons which I will elaborate on below. https://www.nichd.nih.gov/health/topics/pku/conditioninfo/faqs. Phenylketonurics have a genetic defect that makes their body unable to help create a vital enzyme. Phenylketonuria (PKU) is a genetic condition that passes to children from their parents in an autosomal recessive pattern. What is phenylketonurics? Phenylketonuria (PKU) is a lifelong condition and most people living with it lead healthy lives. Since diagnosis and treatment of phenylketonuria (PKU) most often occur shortly after birth due to an abnormal newborn screen, noticeable symptoms are very rare. But what is phenylketonurics? In the past, children were taken off the low protein PKU diet at age 5 or 6 because it was believed that at this age the brain had developed to the point where elevated levels of phenylpyruvic acid in the blood would not cause severe health problems. Long story short, Phenylalanine is an essential amino acid along with Tyrosine. When they can't, it . Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Medically reviewed by Drugs.com. Phenylketonurics is a term that describes those who have PKU. Lichter-Konecki U, et al. Just think of it in light of the term, diabetics, which refers to those who have diabetes. But, if this was not possible, such babies will develop signs and symptoms related to the disease in few months time. Terms of use. (With Pictures and Videos), Garcinia Cambogia Review: Does It Work For Weight Loss. Phenylalanine occurs naturally in many protein-rich foods, such as milk, eggs and meat. All individuals inherit two copies of most genes. WARNING: Phenylketonurics - Contains Phenylalanine. If you have PKU, the severity of your condition would depend on what type of PKU you have. Phenylalanine is also sold as a dietary supplement. All Rights Reserved. Your in-depth digestive health guide will be in your inbox shortly. Drugs. Aspartame. PKU babies will tend to have blond hair, blue eyes, and fair skin. Mayo Clinic. As such, when they eat anything that contains Phe, This amino builds up in their body. Woolworths Prepared Meals: Lowest to Highest Calories, Simmone Logue Meals, calorie ranked Lowest to Highest, Calorie Calculator (How Many Calories per Day to lose weight). Umbrella organizations provide a range of services for patients, families, and disease-specific organizations. Exaggerated Claims About the Harmful Effects of Aspartame. This chemical is considered to be very unsafe by many people (including medical professionals). The artificial sweetener aspartame (Equal, NutraSweet), which is added to many medications, diet foods and diet sodas, contains phenylalanine. Accessed Jan. 28, 2022. Have you ever looked at the label on a diet soda can and seen the warning: Phenylketonurics - contains phenylalanine? Children and adults also need to avoid certain other foods and beverages, including many diet sodas and other drinks that contain aspartame (NutraSweet, Equal). PKU is an incurable condition which when untreated can result in microcephaly (abnormally small head) and many mental disorders and intellectual disabilities. A dangerous buildup of phenylalanine can develop when a person with PKU eats protein-rich foods, such as milk, cheese, nuts or meat, or grains such as bread and pasta, or aspartame, an artificial sweetener. Learn more about PKU in this article. https://www.fda.gov/Food/IngredientsPackagingLabeling/FoodAdditivesIngredients/ucm397725.htm#Aspartame. And they have to order special bread (or make it from scratch), low protein cheese, low protein pastas and a few special low protein chocolates. Thanks for visiting. This has led many to jump to the conclusion that phenylalanine is poisonous. The most severe form is known as classic PKU. Early during a diagnosis, it may be difficult to choose foods that dont contain phenylalanine. I myself, am one of these phenylketonurics and the warning on diet soda cans is included merely to inform people like me that the product contains the synthetic chemical ASPARTAME . Why Do We Say a Fifth of Whiskey, Rum, or Vodka? National Organization for Rare Disorders, Inc. U.S. Department of Health & Human Services. If you have PKU and are considering getting pregnant: Mayo Clinic does not endorse companies or products. Because of this, use products with aspartame cautiously if you: If you aren't sure if phenylalanine or aspartame is a concern for you, talk to your doctor. information and will only use or disclose that information as set forth in our notice of Two carriers have a 25% chance of having an unaffected child with two unaffected genes (left). After diagnosis, regular blood tests to monitor the level of phenylalanine in your blood are necessary. Phenylketonurics is a term for people that have a metabolic disorder called PKU (or Phenylketonuria). Genetics in Medicine. Because these organizations include the life experiences of many different people who have a specific disease, they may best understand the resources needed by those in their community. And it can happen when a person with PKU eats a protein food or aspartame. If you plan on becoming pregnant and want to understand your risk of having a child with a genetic condition, talk to your healthcare provider about genetic testing. Experts say that even grains like pasta and bread, as well as aspartame, can cause problems for phenylketonurics. ), Fast Fuel Meals Calories, Lowest to Highest. Simply put, "Phenylketonurics" means "People who suffer from Phenylketonuria", whilst "phenylalanine" is the name of a particular essential amino acid which cannot be made in the human body. This enzyme is what your body uses to process Phe. Well, lets start by clearing the air. Dietary protein and protein substitute requirements in adults with phenylketonuria: A review of the clinical guidelines. https://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm397716.htm. These organizations usually have information and services focused more on the medical condition(s), but may also have information about associated diseases. This is why experts refer to this inheritance pattern as autosomal recessive. The nervous system is made up of the brain, spinal cord, and nerves. Additionally, phenylalanine is found in aspartame, the sweetener found in most diet soft drinks and sugar-free candies/gum - hence the need for the warning on the labels of these products. When babies are born in the United States, a heel stick blood test is done to test for various disorders - PKU is one of the disorders that is tested for. This list does not include every symptom. I have seen the effects of aspartame toxicity and have discussed symptoms of aspartame poisoning with literally hundreds of people who have found this website. Accessed Nov. 14, 2018. Review/update the Normally, the phenylalanine hydroxylase enzyme acts to convert phenylalanine to tyrosine. Your email address will not be published. Does soy really affect breast cancer risk? Yes, parents are limited in what they can give their child with this disease. Symptoms are worse among severe cases in those who are untreated. In fact, in some cases, (myself included) people with PKU view their disorder as being a positive trait, one which has taught them to be more self-disciplined. National Center for Advancing Translational Sciences, Folling disease; Oligophrenia phenylpyruvica; PKU; Phenylalanine hydroxylase deficiency. Nature Reviews Disease Primers. People with PKU have a deficiency of an enzyme which is necessary for the proper metabolism of an amino acid called Phenylalanine (i.e., the component in diet soda included in the warning). L-phenylalanine is found naturally in foods such as meat and eggs. Those who only inherit the defect from one parent are PKU carriers and known asPKU heterozygotes. Is a low-protein diet enough to reduce my phenylalanine levels or do I need medication? Phenylketonuria is a genetic metabolic disorder that results when the PKU gene is inherited from both parents. Phenylalanine isn't a health concern for most people. Thats why dangerous toxicity might occur when a person with this defective gene eats protein foods. The number of copies of a gene that need to have a disease-causing variant affects the way a disease is inherited. Your body is sensitive to phenylalanine. For this reason, there is no need to include food warnings on every carton of eggs and every block of tofu. BioMarin Pharmaceuticals, Inc.; 2020. https://www.palynziq.com/. Mild hyperphenylalaninemia (least severe). Phenylalanine is a substance the body uses to make other proteins that are needed for normal growth. PKU is caused by a change in the phenylalanine hydroxylase (PAH) gene. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Available Health Products from Mayo Clinic Store, Book: Mayo Clinic Family Health Book, 5th Edition, Book: Mayo Clinic 5 Steps to Controlling High Blood Pressure, Newsletter: Mayo Clinic Health Letter Digital Edition, Artificial sweeteners and other sugar substitutes, Autism spectrum disorder and digestive symptoms, Bad food habits at work? Aspartame has phenylalanine as an ingredient, but is itself a completely different chemical. The PAH gene gives your body instructions to make an enzyme (phenylalanine hydroxylase) that's responsible for converting amino acids into components (proteins) that your body can use. information submitted for this request. Review/update the Based on the number of emails I have received from people like yourself, I believe that the effects of aspartame toxicity are more common than people realize. Are Phenylketonurics bad for you? What is phenylketonuria (PKU)? Also, the fact that the amino is not converted to tyrosine causes a lack of tyrosine in the body. A medication called Pegvaliase (Palynziq) allows people with PKU to eat an unrestricted diet without any supplements or Kuvan. Bodamer OA, et al. Boyer SW (expert opinion). Our bodies break down the protein in foods, such as meat and fish, into amino acids, which are the "building blocks" of protein. Give your child a low-protein diet, including rice, pasta, tortillas, bagels, breads, and egg substitutes and imitation cheeses. Hence the warning! When babies are born in the United States, a heel stick blood test is done to test for various disorders - PKU is one of the disorders that is tested for. This can eventually lead to serious health problems. Aspartame in large doses can cause a rapid increase in brain levels of phenylalanine. If babies are put on the low protein diet at a young age, and they follow the diet throughout life, there is no evidence that their PKU will be a major hindrance in their accomplishments.

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